Serum metabolomics in the hyperlipidemia hamster model demonstrated that lipid metabolism could be returned to normal and gut microbiota reestablished with metronidazole treatment. Atorvastatin competitively inhibited HMG-CoA reductase in the liver to decrease cholesterol and increase LDL receptor synthesis thus decreasing LDL-C, an effect consistent with its preventive and therapeutic role in atherosclerosis. Protein metabolism was also impacted, thus returning glutamine and glucogenic amino acids to nascent levels. Atorvastatin restored the levels of ketone bodies, acetoacetate, acetone, and 3-hydroxybutyrate to normal. In another study, 1H NMR-based metabolomics were used to monitor plasma and liver profiles following Atorvastatin treatment. In contrast, estrone, cortisone, proline, cystine, 3-ureidopropionic acid, and histidine were associated with Atorvastatin-induced liver toxicity. In response to treatment, metabolite profiling suggested restoration of “healthy” metabolism. Metabolic profiling of plasma and tissue (liver, aorta, cardiac muscle, and brain) following oral administration of these drugs was analyzed by MS coupled with multivariate data analysis in rabbit and rat models. Metabolomics has been utilized to explore the therapeutic effect of antilipemic drugs such as Atorvastatin and Simvastatin. Apart from chemical therapeutics and TCM, food itself can exert a hypolipemic effect, i.e., fish oil, Pu-erh tea, Auricularia auricula, and Hawthorn. These antilipemic TCMs can be grouped into three categories: (1) herbs promoting excretions, generally by reducing food retention, enhancing purgative effect, and promoting diuresis and choleresis (2) herbs acting on the cardiovascular system, generally by improved blood circulation (3) herbs that have tonic effect. Interestingly, more than 50 traditional Chinese medicines (TCM) have also been used to treat hyperlipidemia. Rui-Chao Lin, in Advances in Clinical Chemistry, 2014 6.1.2 Antilipemic agent researchĬurrently, statins, fibrates, nicotinic acid, and cholesterol absorption inhibitors remain the main therapeutics to reduce circulating lipids. The fungus can be found throughout the year in temperate regions worldwide, where it grows upon both dead and living wood.Īrabic: أذن يهوذا, Bulgarian: Юдино ухо, Cantonese: 雲耳, Catalan: Orella de Judes, Chinese: 黑木耳, Croatian: Judino uho, Czech: Ucho Jidášovo, Danish: Almindelig judasøre, Dutch: Judasoor, Esperanto: Judasorelo, Finnish: Juudaksenkorva, French: Oreille de Judas, German: Judasohr, Hakka Chinese: Muk-mí, Hebrew: אזנונית יהודה, Hungarian: Júdásfülegomba, Indonesian: Jamur kuping merah, Japanese: キクラゲ, Javanese: Jamur kuping abang, Korean: 목이, Limburgish: Judasoeër, Malayalam: ചെവിക്കൂൺ, Min Dong Chinese: Mŭk-ngī, Mon: လဇု၊ ပတိုဟ်, Persian: قارچ گوشژلهای, Piedmontese: Hirneola auricula-judae, Polish: Uszak bzowy, Quechua: Linli, Romanian: Urechea lui Iuda, Russian: Аурикулярия уховидная, Serbian: Јудино уво, Sundanese: Lémbér beureum, Swedish: Judasöra, Thai: เห็ดหูหนู, Ukrainian: Аурикулярія вухоподібна, Vietnamese: Nấm mèo, Walloon: Oraye di Djuda.Hua Chen. Its specific epithet is derived from the belief that Judas Iscariot hanged himself from an elder tree the Latin Judae ('Judas's') was mistranslated into English as 'Jew's', leading to the term "Jew's ear", while today "jelly ear" and other names are sometimes used. The fruiting body is distinguished by its noticeably ear-like shape and brown colouration it grows upon wood, especially elder. Synonyms: Auricula auricularis, Auricularia albicans, Auricularia auricula, Auricularia auricularis, Auricularia judae, Auricularia lactea, Auricularia mollissima, Auricularia nidiformis, Auricularia sambuci, Auricularia sambucina, Auricularia tremellosa, Auricula tremellosa, Exidia auricula, Gyraria auricularis, Hirneola auricula, Hirneola auricularis, Hirneola nidiformis, Laschia tremellosa, Merulius auricula, Peziza auricula, Tremella auricula, Tremella caraganae.Įxtract from Wikipedia article: Auricularia auricula-judae (Latin for 'Judas's Ear'), known as the Jew's ear, (black) wood ear, jelly ear or by a number of other common names, is a species of edible Auriculariales fungus found worldwide.
![auricularia auricula judae auricularia auricula judae](https://live.staticflickr.com/3835/14324520627_6deb5c60fe.jpg)
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Fungi: Basidiomycota: Agaricomycetes: Auriculariales: Auriculariaceae: Auricularia auricula-judae (Bull.) Quél.